SKIN DIS
SKIN DIS
By Ashenafi Z
JANUARY, 2024
01/01/2025
2 Presentation outline
Introduction
Inflammatory& allergic reactions of the skin
Bacterial skin infection
Viral skin infections
Fungal skin infection
Parasitic skin infestation
Non infectious inflammatory dermatoses
Benign tumors and skin cancer 01/01/2025
3 Morphology of skin lesions
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Primary lesions
4
o macula - spot
o Flat, change in skin color <1.0cm
o No elevation or depression
o Not identified by mere touch
o Patch ---- >1.0cm
Papule
Papula - pimple
Small solid elevation
< 0.5cm in diameter
Epidermal, dermal or 01/01/2025
combined changes
Nodule
5 Nodulus - ‘small knot’
Palpable, solid, round lesion
big papule
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Pustule
6 Small pus containing swelling
Usually ass. with infection
from papules or vesicles
May develop denovo e.g. acne
Wheal
Round or flat topped red, purple papule
Disappears in hours or a day or two
Due to edema in the upper dermis
If lower----SC---Angioedema
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Plaque
7 palpable lesions >1 cm in
size and have a flat surface
Tumor
Elevated, palpable, solid mass or cystic
elevation >2 cm in diameter extends deeper
into the dermis
Cyst
Encapsulated fluid-filled or semisolid mass
in the subcutaneous tissue or dermis
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Secondary lesions
8 Erosion, ulcer
Types of tissue loses varying in their
depth and breadth
Erosion: confined to the epidermis
Ulcers: larger defect involving the dermis
and SC
Fissures
Linear crack in the skin, may extend to
dermis
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Scales
Flakes secondary to desquamated, dead
9 epithelium
Varies in color and texture
Crust
dried residue of serum, blood, or pus on skin
surface
Scar
skin mark left after healing of a wound or lesion
Keloid
hypertrophied scar tissue
Secondary to excessive collagen formation
during healing (elevated, irregular, red) 01/01/2025
Diagnostic evaluation of skin problems
1 1. History and physical examination
0 The diagnosis of a skin disorder is made chiefly by visual
inspection, but some skin disorders may require additional testing
2. Skin biopsy
Is performed to obtain tissue for microscopic examination
by scalpel excision or by a skin punch instrument that removes a
small core of tissue. Eg malignancy and exact dxs
3. Skin scraping
Tissue samples are scraped from suspected fungal lesions with a
scalpel blade moistened with oil and examined microscopically
. 01/01/2025
4. Wood’s light examination
1 Is a special lamp that produces long-wave ultraviolet rays, where it is
1 possible to differentiate epidermal from dermal lesions and hypo
pigmented and hyper pigmented lesions from normal skin.
5. Tzanck smear
The Tzanck smear is a test used to examine cells from blistering skin
conditions and The secretions from a suspected lesion are applied to a
glass slide, stained, and examined
6. Culture and sensitivity
To confirm the causative agent and drugs to which they are sensitive
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1.Inflammatory& allergic reactions of the skin
1 Dermatitis is an inflammation of the skin.
2 It is a common condition and not life-threatening or contagious.
Several types of dermatitis (eczema) Causes
Atopic dermatitis Allergies
Contact dermatitis Genetic factors
Seborrheic dermatitis Physical and mental stress
Neuro dermatitis Irritants
Stasis dermatitis
Perioral dermatitis
S/S :- redness, swelling, itching and skin lesions. 01/01/2025
Contact dermatitis
1 Acute or chronic inflammatory skin disorder
3 Characterized by well demarcated skin lesions
History of exposure to suspected offending
agent
Types:- Irritant contact dermatitis
Allergic contact dermatitis
Causes
Irritant substances Ex: Detergents,
hair metals, perfumes, strong acids &
alkalis induce irritant contact dermatitis
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S/S
o Erythematous
1
4 o Macular, papular or papulo-vesicular
eruptions,
o chiefly involving the exposed part of the
body
o Pruritus is common
Mgt
Avoid the agent
Topical steroids and if severe systemic for
a short time
Antipruritics
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and infection
1
6
S/S :-Pruritus, redness, papule,
thickening of skin
Exacerbations & remissions of s/s
Common over face & neck, behind
the knee & back of the hand.
Prevention of infection
Seborrheic dermatitis
1 Called dandruff in the scalp
7 Cause not fully understood
Associated factors:
Genetics
Immunosuppression
Yellowish red, often greasy, or white
dry scaling macules and papules
Mgt
Selenium sulfide shampoo
Ketoconazole shampoo
Topical steroids 01/01/2025
Acne
result from blockages in sebaceous gland follicles
1 Causes:- exactly unknown
8 Family history
Hormonal activity
Hyperactive sebaceous glands
Accumulation of dead skin cells
Types:- Acne vulgaris :- adolescent
Acne Rosacea:- uncommon < 30 yrs
S/S:- Whiteheads or blackheads of Nodules /red
lesion pustules, Scarring, Comedo
Mgt:- cleaning and removal of oils
Keep the skin clean
Antibiotics 01/01/2025
Corticosteroids
2. Bacterial skin infection
1 Boil (furuncle)
9 inflammation of hair follicles accumulation
of pus & dead tissue
Etiology:- staphylococcus auerus or
streptococcus
S/S:- Red, shiny, & swollen pus-filled lump
Tenderness, warm&/or painful
Fever & swollen lymph nodes if sever
When the lump is ready to rupture, a pointy
white or yellow central area is noticed.
Mgt:- Surgical drainage(incision & drainage)
Systemic antibiotics 01/01/2025
o
Impetigo
2 superficial skin infection
1 More common in children and contagious
caused by either Staphylococci or
Streptococci
Two clinical syndromes
1.Non bullous
most common 70 percent
The face (especially around the nares)
commonly affected.
vesicle or pustule that quickly evolves into a
honey-colored crusted plaque. 01/01/2025
Treatment :- Acyclovir
Warts
Minor surgery
MOLLUSCUM CONTAGIOSUM
2 Large double stranded DNA viral infection
7 Affects children age 2-6 yrs and immunosuppressed
individuals
Spread by person to person contact
S/S:- Small raised pink bumps with dimple in center,
“umbillicated”
The face, eyelids, neck, axillae, and thighs
commonly involved
Mgt
Mostly self-limited
Immunotherapy 01/01/2025
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Pediculosis: lice infestation
They inject their digestive juices and excrement into the skin, which
3 causes severe itching
3 Serves as a vector of human disease
They depend on the host for their nourishment, feeding on human
blood approximately five times each day
disease of unwashed people or those who live in close quarters and
do not change their clothing
Types Pediculosis capitis
o Pediculosis corporis and
o Pediculosis pubis
S/S:- eggs are visible to the naked eye
Itching and scratching, Reddish brown dust
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Mgt
3
Lindane(1%,1-2oz apply for 4 mins) then
4
Wash with a shampoo/lotion containing or Pyrethrin(1%)
Permethrin1% is applied to affected areas of the skin and
to hairy areas
All articles, clothing, towels, and bedding that may have
lice or nits should be washed in hot water—at least 54°C
(130°F)
All family members and sexual contacts must be treated
personal hygiene education
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5.Non infectious inflammatory dermatoses
3 Psoriasis
5 Is a chronic noninfectious inflammatory and
incurable skin disease
An autoimmune-related disease
Characterized by inflammation and altered
keratinocyte proliferation
has a complex multifactorial genetic basis
Risk factors
Family history(50% pts)
medical conditions and medication
Stress Obesity
Smoking infections 01/01/2025
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skin cancer
3 Skin cancer can be classified in to two
9 Melanoma and
Non melanoma
Non melanoma is classified in to two
Basal cell carcinoma and
Squamous cell carcinoma
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40
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