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PHARMA ENGINEERIN
SCALE - UP CALCULATOR

I / O parameters UOM
Input Details
Batch Size * Kg
Reaction mass volumes * -
Reactor capacity KL
L/D ratio -
Agitator Dia * m
Agitator * -
RPM * -
Reaction solvent * Kg/m3
Output Details
Reaction mass volume L
Occupancy %
Cylindrical height m
Reactor ID m
Agitator Shaft length m
Percentage Sweep %
Torispherical Volume m3
Cylindrical volume m3
Total Reaction mass volume m3
Reaction mass volume in cylinder m3
Cylindrical height of reaction mass m
L/D ratio of reaction mass -
cP
Viscosity of reaction mass
Pa.S
Desnity of reaction mass Kg/m3
Reynolds Number NR
Power Number NP
RPS (N) Sec-1
J/S
Power
KW
Shaft Torque N-m
Power per unit volume P/V

RESULT :
RMA ENGINEERING
CALE - UP CALCULATOR

Existing Proposed
Input Details
30 76
17.58 17.58
1 3
1.05 1.28
0.46 0.56
Flat blade turbine Axial flow turbine- 4 bladed
96 150
Toluene Toluene
Output Details
527.4 1336.08
52.74 44.54
1.03 1.69
0.98 1.32
1.28 2.02
0.47 0.42
0.09 0.23
0.78 2.32
0.53 1.34
0.43 1.11
0.57 0.81
0.58 0.61
0.65 0.65
0.000649 0.000649
910.35 910.35
474896.91 1099714.02
5 1.4
1.60 2.50
384.00 1096.72
0.38 1.10
38.20 69.83
0.73 0.82

ESULT : Feasible
Reynolds No. Power No.
5 85
7.5 58
10 33
25 18
50 12
75 7
100 5
250 3.5
500 2.2
750 1.75
1000 1.4
2500 1
5000 0.85
7500 0.75
10000 0.6
25000 0.5
50000 0.45
100000 0.4
2500000 0.38
5000000 0.37
7500000 0.36
1000000 0.35
Nre
100
Loss 10 %
90
Profit 11.11111 %
100
Reactor Capacity L/D Agitator
0.05 1 Anchor
0.063 1.02 Paddle
0.1 1.04 Gate
0.16 1.05 Marine Propeller - 3 bladed
0.2 1.07 Marine Propeller - 4 bladed
0.25 1.09 Turbo impeller - 3 bladed
0.5 1.12 Turbo impeller - 4 bladed
0.63 1.15 Turbo impeller - 5 bladed
0.75 1.18 Turbo impeller - 6 bladed
1 1.2 Axial flow turbine- 3 bladed
1.2 1.22 Axial flow turbine- 4 bladed
1.5 1.25 Axial flow turbine- 5 bladed
1.6 1.28 Axial flow turbine- 6 bladed
2 1.31 Disc blade turbine
2.5 Flat blade turbine
3 Back blade turbine
4

5
6
7

7.5
8
10

12
13
15
Power number Marine propeller Turbo impeller
5 No. of impeller Np No. of impeller Np
5 3 bladed impeller 0.3 3 bladed 1.35
5 4 bladed impeller 0.33 4 bladed 1.4
0.3 5 bladed 1.45
0.33 6 bladed 1.6
1.35 Axial flow turbine
1.4
1.45 3 bladed 1.35
1.6 4 bladed 1.4
1.35 5 bladed 1.45
1.4 6 bladed 1.6
1.45
1.6
5
5
5
Solvent SP Viscosity
n-Pentane 0.626 0.235
n-Hexane 0.659 0.31
n-Heptane 0.664 0.41
n-Octane 0.703 0.5
Cyclohexane 0.778 0.98
Benzene 0.879 0.65
Toluene 0.867 0.59
Methanol 0.792 0.6
Ethanol 0.789 1.08
n-Propanol 0.804 1.72
IsoPropanal 0.786 2
n-Butanol 0.81 3
sec Butanol 0.807 3.7
n-Amyl alcohol 0.815 4
1,2-Ethanediol 1.115 20
Diethylene glycol 1.118 34
1,2-Propanediol 1.0362 54
CycloHexanol 0.949 52.7
Propylene glycol methyl
0.924 1.9
ether
Methyl Cellosolve 0.966 1.6
Ethyl Cellosolve 0.931 2.5
Butyl Cellosolve (Butyl
0.902 6.4
glycol)
MDC 1.326 0.44
Chloroform 1.48 0.57
1,2 DiChloro Ethane (EDC) 1.253 0.9
Tri Chloro Ethylene 1.464 0.57
Per Chloro Ethylene 1.63 0.88
Mono Chloro Benzene 1.106 0.8
Acetone 0.79 0.33
Methyl Ethyl Ketone 0.805 0.41
MIBK 0.801 0.61
Cyclo Hexanone 0.948 2.2
n-Methyl-2-pyrolidone 1.03 1.8
Acetophenone 1.024 1.74
Di Ethyl Ether 0.715 0.24
Di iso Propyl Ether 0.724 0.33
Di butyl ether 0.769 0.63
Methyl tert butyl ether 0.741 0.35
1,4 Diaoxane 1.034 1.3
Tetra Hydro Furan 0.888 0.55
Methyl Acetate 0.927 0.37
Ethyl Acetate 0.895 0.46
Isopropyl Acetate 0.874 0.46
n-Butyl Acetate 0.876 0.73
Di Methyl Formamide 0.945 0.82
DiMethyl Acetamide 0.945 0.92
Di methyl Sulfaoxide 1.101 2
Sulpholane 1.26 10.3
Carbon disulphide 1.26 0.36
Nitrobenzene 1.204 1.8
Pyridine 0.983 0.88
2-Nitropropane 0.992 0.74
Acetonitrile 0.782 0.38
Furfuraldehyde 1.16 1.4
Phenol 1.058 4.3
Water 1 1