In Chapter 15, the final room contains a bench/store and save point. Backtrack down the corridor. There is a room that you must open with a Power Node, it contains 2 Power Nodes, a Ruby Semiconductor and some random items. Collect them and return to the save point. Save your game and reload it. Return to the locked Node room again and the items will have returned! You can repeat this process indefinitely.
You can also do this at the Node-locked rooms in Chapter 6, Chapter 7 and Chapter 14.
Additions by Josh Myers, andre droesher and N
In Chapter 15, the final room contains a bench/store and save point. Backtrack down the corridor. There is a room that you must open with a Power Node, it contains 2 Power Nodes, a Ruby Semiconductor and some random items. Collect them and return to the save point. Save your game and reload it. Return to the locked Node room again and the items will have returned! You can repeat this process indefinitely.
You can also do this at the Node-locked rooms in Chapter 6, Chapter 7 and Chapter 14.
A...
If you've purchased the Supernova or Martial Law DLC packs, you have access to a free Detonator weapon. Go to the Store and buy the weapon for 0 credits. Fire the mines at a nearby wall, then deactivate and retrieve them. DO NOT RELOAD! Sell the mines at the store for credits and sell the free Detonator. Buy it back -- it now has full ammo again so you can repeat this indefinitely!
In Chapter 7, locate the mainframe room where ANTI is. One of the circuit rooms will have breakers that turn blue in addition to being green or red (it's the left breaker room, if ANTI's hologram emitters are behind Isaac). Insert the four breakers in that circuit room so they are blue, and the access tunnel leads to the Peng Treasure.
Attain the following levels in multiplayer to unlock additional gear.
Human
Necromorph
Attain the following levels in multiplayer to unlock additional gear.
Human
Perform the following actions to unlock these special suits in the store.
Single-Player Suits
Multiplayer Suits
Additions by Mike Clark
Perform the following actions to unlock these special suits in the store.
Single-Player Suits
Perform the following actions to unlock additional modes.
Perform the following actions to unlock additional modes.
At the start of Chapter 7, Isaac may re-spec his weapons, RIG, and stasis module. This ability lets him take out all the power nodes in a piece of equipment and re-assign them elsewhere. Each time you "re-spec" an item, it will cost 5000 CR. While it won't help you get the Trophy/Achievement for upgrading all your equipment, it is handy to re-assign (or take back) power nodes from weapons you don't use anymore.
You can use the shop and the work bench to get easy health boosts. Each time you don a suit for the first time -- after buying it in the shop -- your health is filled to maximum. This only works the first time you put on each suit, but with the extra downloadable suits you can do this several times throughout the game.
Alternately, once you can purchase the Respec ability (5000 Credits), you can strip the Power Nodes from the Rig and replace them for full health -- this costs less than, say, buying a large health pack.
You can use the shop and the work bench to get easy health boosts. Each time you don a suit for the first time -- after buying it in the shop -- your health is filled to maximum. This only works the first time you put on each suit, but with the extra downloadable suits you can do this several times throughout the game.
Alternately, once you can purchase the Respec ability (5000 Credits), you can strip the Power Nodes from the Rig and replace them for full health -- this costs less than, say,...