Annals of Intensive Care

Thrombocytopenia, defined as a platelet count below 150 × 10⁹/L or a significant drop from baseline, is a common disorder in critically ill patients and linked to poor outcomes. Causes vary with clinical context, although it is always associated with an increased bleeding risk.
Platelet transfusion is the main treatment, though evidence guiding prophylactic thresholds in ICU settings is limited. Current practices often rely on data from stable hematology patients, while transfusion thresholds for invasive procedures or severe bleeding remain largely empirical.
This review by Frédéric Pène et al. provides a comprehensive overview on the epidemiology and aetiologies of thrombocytopenia in critically ill patients, the bleeding risk assessment in thrombocytopenic patients, and the platelet transfusion indications.

Annals of Intensive Care is presenting a new Collection of papers aiming is to feature original research and review articles that bring together manuscripts that cover all of these aspects of fluid therapy.

Annals of Intensive Care is presenting a new Collection on "Physiology applied to ICU".

Annals of Intensive Care is presenting a new Collection of papers aiming to provide a comprehensive overview of the latest research, clinical practices, and emerging therapies related to coagulation and hemostatic disorders in critically ill patients.

We invite authors to submit to our new Collection focusing on Biomarkers in critically ill patients. Key topics we would like to cover in this collection include: early diagnosis, risk assessment, treatment response, biological feasibility, ease of measurement, rapid results, and cost-benefit analysis.

Annals of Intensive Care presents a Collection of papers aiming to help translate the recent findings into improvements in the quality of care by individualized metabolic and nutritional management.

Sepsis-related circulatory failure results from complex mechanisms including vascular dysfunction, hypovolemia, and myocardial depression. Septic shock is commonly associated with reduction in vasomotor tone, mainly due to vascular hyporesponsiveness to norepinephrine (NE). 
A. Goury et al. conducted a post-hoc analysis of the ANDROMEDA-SHOCK database and found that the Vascular NE Responsiveness Index (VNERi) was the strongest predictor of outcomes in early septic shock patients receiving norepinephrine.
VNERi outperformed other hemodynamic variables in predicting mortality, vasopressor-free days, and RRT-free days, suggesting its potential as a bedside marker. This index could potentially be integrated into decision-making of early septic shock.

Acute encephalopathy is a syndrome characterized by a rapidly developing pathobiological brain process which is expressed clinically either as delirium or coma, both representing a change from baseline cognitive status.
Acute encephalopathy in ICU patients presents significant diagnostic, therapeutic, and prognostic challenges, yet standardized expert guidelines remain limited.
To address this gap, a panel convened by the French Intensive Care Society (SRLF) developed 39 recommendations using the GRADE methodology, covering ICU admission criteria, diagnostic tools, monitoring strategies, and acute management.
This expert consensus statement aims to standardize care, improve outcomes, and guide future research by integrating evidence-based practices with expert clinical judgment.

Annals of Intensive Care encourages authors to submit a visual abstract along with their manuscripts. As an author submitting to the journal, you may wish to make use of services provided at Springer Nature for high quality and affordable visual abstracts where you are entitled to a 20% discount. Click here to find out more about the service, and your discount will be automatically be applied when using this link.